The Lexus LS comes with comprehensive safety equipment, featuring the Lexus Safety System+ including Pre-Collision System (autonomous emergency braking), DRCC radar cruise control, LDA lane departure alert with steering assist, BSM blind spot monitoring, and RCTA rear cross traffic alert. It also includes 10 airbags, a 360-degree panoramic view monitor, ICS intelligent parking assist, and ISOFIX child seat anchors throughout the cabin.
Lexus LS 嘅安全設備非常齊全，標準配備 Lexus Safety System+，功能包括預警式防護系統（自動煞車輔助）、DRCC 雷達感應車距定速巡航、LDA 線道偏離警示連轉向輔助、BSM 盲點偵測、RCTA 後方橫向車流警示。另外仲有 10 個安全氣囊、360 度環視鏡頭、ICS 智能泊車輔助系統，以及全車嘅 ISOFIX 兒童座椅接口。
